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Differences between boys and girls in the language domain are also present, but are substantially less pronounced. Boys have a greater risk for late language emergence (2.4:1) (30), but specific language impairment (a disorder when only language system is affected, with typical development of cognitive and communication skills) is just slightly more prevalent in preschool boys than in girls (20%-30% higher) (32,33). Similarly, dyslexia has a prevalence ratio of 1.5:1 in the population of school children (36). Although these discrepancies are significant and should not be understated, they are considerably smaller than differences in the prevalence of communication disorders (ASD and social communication disorder).

Neurogenetic markers of language skills have first been studied in FOXP2 gene. FOXP2 seems to enable the unique verbal communication in humans and is one of the most studied genes in language research (56). FOX2 gene exists in other mammals as well, but humans have a specific variation of the gene. However, even in rat pups, sex differences in ultrasonic vocalizations were eliminated by decreasing the amount of Foxp2 in their brain (57), which implies that this gene might be a component of the neurobiological basis for sex differences in mammal vocal communication. FOXP2 in humans, compared to other mammals, experienced two amino acids changes, and it is known that for the development of normal language skills, the human genome is required to have two functional copies of human-specific FOXP2 (58). Otherwise, certain FOXP2 mutations induce severe articulation difficulties and linguistic and grammatical impairment (59). Interestingly, in a small sample of 4-year-old children, the amount of FOXP2 protein in the left hemisphere was significantly lower in boys than in girls (57). Other genes that are known to be involved in language development often have a crucial role in modulating certain brain processes, including neuronal migration, cell adhesion, or axon guidance (ROBO1, ROBO2, KIAA0319, DYX1C1, CNTNAP2), as well as calcium homeostasis (ATP2C2) (60). Further studies are needed to investigate the possible sex differences in the expression of these (and other) genes, but some studies on gene expression in autism imply possible sexually dimorphic pathways (61).

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Currently, it seems more common for pimps who profit from selling their victims to others to be identified in the trafficking of girls, while that seems to be less common with boys, who seem to be targeted by those who exploit their vulnerabilities to get their basic needs met. Both boys and girls are also sold for sex by their family members or guardians. These factors can contribute to the trafficking of boys being much more hidden.

The NCMEC analysis of 565 boys also showed that, like girls, they also face a raft of other endangerments while on the run, including drugs and alcohol, mental health diagnoses, suicidal tendencies, special needs issues and carrying weapons. Many run away frequently.

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